| 11. | Aldolase A is found in the developing embryo and is produced in even greater amounts in adult muscle.
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| 12. | In mammalian aldolase, the key catalytic amino acid residues involved in the reaction are lysine and tyrosine.
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| 13. | Compromised immunity has also been indicated, relating to the predominance or exclusivity of aldolase A in leukocytes.
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| 14. | Characterised as a recessive disorder, symptomatic presentation requires the inheritance of aldolase A mutations from both parents.
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| 15. | In particular this leads to a complication for clearly delineating the effects of enzymatic aldolase-A deficiency.
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| 16. | However, unlike in the primary instance parental aldolase activity was also partially reduced without significant physiological ailment.
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| 17. | In particular neurological impairment was conjecturally linked with the predominant role of aldolase A in the brain during development.
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| 18. | KDPG Aldolase was recently determined to be a trimer through crystallographic three-fold symmetry, with 225 residues.
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| 19. | Another part of the explanation was the presumed complexity of aldolase catalysis that dominated chemical thinking for a long time.
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| 20. | Plants and algae have plastidal aldolase, sometimes a relic of endosymbiosis, in addition to the usual cytosolic aldolase.
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