| 11. | ACE inhibitors block ACE, the enzyme that among other actions, degrades bradykinin.
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| 12. | Treatment of A431 cells with bradykinin reduces basal and EGF-induced EGFR phosphorylation.
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| 13. | Currently, bradykinin inhibitors ( hereditary angioedema.
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| 14. | Other less known functions of ACE are degradation of bradykinin and amyloid beta-protein.
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| 15. | HMWK is also a precursor of bradykinin; this vasodilator is released through positive feedback by kallikrein.
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| 16. | When mechanisms for the degradation of bradykinin are impaired, the peptide builds up and causes hypotension.
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| 17. | A genetic predisposition may exist toward this adverse effect in patients who degrade bradykinin more slowly than average.
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| 18. | Moreover, plasmin induces the generation of bradykinin in mice and humans trough high molecular weight kininogen cleavage.
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| 19. | In kidney cells, the bradykinin receptor B2 has been shown to interact directly with a protein tyrosine phosphatase.
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| 20. | ACh also causes the salivary gland to release kallikrein, an enzyme that converts kininogen to lysyl-bradykinin.
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