There are two opposing views on the nature of chondroblastoma, one favoring an plasticity of mesenchymal cells when set into different microenvironments and static approaches used in literature.
12.
Romeo " et al " has noted that chondroblastoma arising in long bones mainly affects the epiphyses, while in other locations it is close to ossification centers.
13.
In a publication by Turcotte et al . it was found that the average duration of symptoms for patients with chondroblastoma was about 20 months, ranging from 5 weeks to 16 years.
14.
Overall, patients with more classical chondroblastoma ( appearing in long bones, typical presentation ) have better prognoses than patients with atypical chondroblastoma ( flat bones, skull, etc . ).
15.
Overall, patients with more classical chondroblastoma ( appearing in long bones, typical presentation ) have better prognoses than patients with atypical chondroblastoma ( flat bones, skull, etc . ).
16.
Additionally, rare prevalence of chondroblastoma in proliferation among the cells in the proliferating / pre-hypertrophic zone ( cellular-rich area ) versus the hypertrophic / calcifying zone ( matrix-rich area ).
17.
While recurrence is the most common complication of chondroblastoma other issues include post-surgery infection, degenerative joint disease, pathological fractures, failure of bone grafts, pre-mature epiphyseal closure, functional impairment, and malignant transformation.
18.
Romeo " et al " have observed chondroblastoma neoplasms to be composed of mesenchymal cells that have completed normal chondrogenesis along with the production of osteoid and collagen I that could be the result of transdifferentiation of chondrocytes towards osteoblasts.
