Tacrolimus has been found to reduce episodes of organ rejection over a related treatment, the drug ciclosporin, which binds cyclophilin.
12.
The protein belongs to a family of isozymes, including cyclophilins B and C, and natural killer cell cyclophilin-related protein.
13.
Parvulin itself contains proline residues and its folding can be accelerated by the presence of cyclophilin; parvulin folding can also be autocatalytic.
14.
This complex of ciclosporin and cyclophilin inhibits calcineurin, which, under normal circumstances, is responsible for activating the transcription of interleukin 2.
15.
As a cyclophilin, PPI binds cyclosporin A ( CsA ) and can be found within in the cell or secreted by the cell.
16.
Inhibiting cyclophilin D has been shown to prevent the opening of the MPT pore and protect the mitochondria and cellular energy production from excessive calcium inflows.
17.
The investigational drug Debio-025 is a known inhibitor of the protein cyclophilin D, which regulates the swelling of mitochondria in response to cellular injury.
18.
CsA binds to cyclophilin D to block the opening of MPTP, and thus decreases the release of protein cytochrome C, which can cause programmed cell death.
19.
It does this by binding to cyclophilin, an multifunctional protein that facilitates protein folding, acts as a protein chaperone, and regulates the activity of other proteins.
20.
Both the FKBP-tacrolimus complex and the ciclosporin-cyclophilin complex inhibit a phosphatase called calcineurin, thus blocking signal transduction in the T-lymphocyte transduction pathway.
