Ciclosporin prevents the dephosphorylation of NF-AT by binding to cyclophilin.
2.
Along with cyclophilin, FKBPs belong to the immunophilin family.
3.
Cyclophilin A is a cytosolic and highly abundant protein.
4.
This gene encodes a member of the cyclophilin family.
5.
Ciclosporin binds to the cytosolic protein cyclophilin ( immunophilin ) of lymphocytes, especially T cells.
6.
When bound to cyclophilin B, cyclosporin A binds and inactivates the key signaling intermediate calcineurin.
7.
Currently, cyclophilin expression is highly correlated with cancer pathogenesis, but the specific mechanisms remain to be elucidated.
8.
However, Cyclophilin A is important for the inhibition of HIV-1 by TRIM5? in Old World monkey species.
9.
Ciclosporin is thought to bind to the cytosolic protein cyclophilin ( an immunophilin ) of immunocompetent lymphocytes, especially T-lymphocytes.
10.
This complex of ciclosporin and cyclophilin inhibits the phosphatase calcineurin, which under normal circumstances induces the transcription of interleukin-2.
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