cyclophilin वाक्य
उदाहरण वाक्य
मोबाइल
- Ciclosporin prevents the dephosphorylation of NF-AT by binding to cyclophilin.
- Along with cyclophilin, FKBPs belong to the immunophilin family.
- Cyclophilin A is a cytosolic and highly abundant protein.
- This gene encodes a member of the cyclophilin family.
- Ciclosporin binds to the cytosolic protein cyclophilin ( immunophilin ) of lymphocytes, especially T cells.
- When bound to cyclophilin B, cyclosporin A binds and inactivates the key signaling intermediate calcineurin.
- Currently, cyclophilin expression is highly correlated with cancer pathogenesis, but the specific mechanisms remain to be elucidated.
- However, Cyclophilin A is important for the inhibition of HIV-1 by TRIM5? in Old World monkey species.
- Ciclosporin is thought to bind to the cytosolic protein cyclophilin ( an immunophilin ) of immunocompetent lymphocytes, especially T-lymphocytes.
- This complex of ciclosporin and cyclophilin inhibits the phosphatase calcineurin, which under normal circumstances induces the transcription of interleukin-2.
- Tacrolimus has been found to reduce episodes of organ rejection over a related treatment, the drug ciclosporin, which binds cyclophilin.
- The protein belongs to a family of isozymes, including cyclophilins B and C, and natural killer cell cyclophilin-related protein.
- Parvulin itself contains proline residues and its folding can be accelerated by the presence of cyclophilin; parvulin folding can also be autocatalytic.
- This complex of ciclosporin and cyclophilin inhibits calcineurin, which, under normal circumstances, is responsible for activating the transcription of interleukin 2.
- As a cyclophilin, PPI binds cyclosporin A ( CsA ) and can be found within in the cell or secreted by the cell.
- Inhibiting cyclophilin D has been shown to prevent the opening of the MPT pore and protect the mitochondria and cellular energy production from excessive calcium inflows.
- The investigational drug Debio-025 is a known inhibitor of the protein cyclophilin D, which regulates the swelling of mitochondria in response to cellular injury.
- CsA binds to cyclophilin D to block the opening of MPTP, and thus decreases the release of protein cytochrome C, which can cause programmed cell death.
- It does this by binding to cyclophilin, an multifunctional protein that facilitates protein folding, acts as a protein chaperone, and regulates the activity of other proteins.
- Both the FKBP-tacrolimus complex and the ciclosporin-cyclophilin complex inhibit a phosphatase called calcineurin, thus blocking signal transduction in the T-lymphocyte transduction pathway.
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