The disease develops as a result of the temporal and spatial loss of the basal epithelial compartment as well as increased proliferation and dedifferentiation of the luminal ( secretory ) epithelial cells.
12.
It is currently unclear as to whether cancer stem cells arise from adult stem cell transformation, a maturation arrest of progenitor cells, or as a result of dedifferentiation of mature cells.
13.
The 8p chromosome is a region that is frequently reported to undergo a loss of heterozygosity ( LOH ) associated with tissue dedifferentiation and loss of androgen responsiveness during the progression of prostate cancer.
14.
Moreover, callus undergoes dedifferentiation as differentiated cells acquire ability to differentiate; but genetic variation is inevitable in the process because the cells consist of somatic undifferentiated cells from an adult subject plant.
15.
"' Callus "', or dedifferentiated cells, are somatic cells that undergo dedifferentiation to give rise to totipotent embryogenic cells, which temporarily gains the ability to proliferate and / or regenerate an embryo.
16.
Some believe dedifferentiation is an aberration of the normal development cycle that results in cancer, whereas others believe it to be a natural part of the immune response lost by humans at some point as a result of evolution.
17.
In addition, recent studies have also proven the importance of this transcription factor in maintaining the myelination phenotype ( and requires the co-expression of Sox 10 ) as its inactivation leads to dedifferentiation of the Schwann cells.
18.
NGN3 + cells isolated from cultured exocrine tissue by coexpressed cell surface glycoprotein CD133 have a transcriptome consistent with exocrine dedifferentiation, a phenotype that resembles endocrine progenitor cells during development, and a capacity for endocrine differentiation in vitro.
19.
Finally, currently most cloning techniques poorly preserve epigenetic modifications ( though there are some that are better for example altering epigenetics is a primary mode by which dedifferentiation techniques dedifferentiate cells, so expect a somewhat different phenotype with these ).
20.
2, 4 D has been used in laboratories for plant research as a supplement in plant cell culture media such as MS medium since at least 1962.2, 4-D is used in plant cell cultures as a dedifferentiation ( callus induction ) hormone.
