Knock-out models of Gelatinase B result in delayed apoptosis, vascularization, and ossification of hypertrophic chondrocytes.
12.
It is expressed by osteoclasts, and is known to be required for osteoclast migration and is a powerful gelatinase.
13.
Gelatinase B, along with elastase, appears to be a regulatory factor in neutrophil migration across the basement membrane.
14.
In in vitro experiments, it has been demonstrated that gelatinase B is greatly upregulated during human respiratory epithelial healing.
15.
Gelatinase B plays a central role in tumor progression, from angiogenesis, to stromal remodeling, and ultimately metastasis.
16.
However, because of its physiologic function, it may be difficult to leverage Gelatinase B inhibition into cancer therapy modalities.
17.
In a mouse model, Gelatinase B deficiency resulted in resistance to endotoxin shock, suggesting that Gelatinase B is important in sepsis.
18.
In a mouse model, Gelatinase B deficiency resulted in resistance to endotoxin shock, suggesting that Gelatinase B is important in sepsis.
19.
Lastly, there is significant evidence that Gelatinase B is required for the recruitment of endothelial stem cells, a critical component of angiogenesis
20.
The treatment has inhibited the ability of cancerous tumors to grow and spread in animal tests by inhibiting gelatinase enzymes that help tumors spread, Celltech said.
