This conference was preceded by a one-day workshop on " Fundamental Approaches in Molecular Diagnosis of Hemoglobinopathies ".
12.
His early research focused on retroviral vector based gene correction of hematopoietic cells from monogenetic disorders, such as hemoglobinopathies.
13.
Some well-known hemoglobin variants such as sickle-cell anemia and congenital dyserythropoietic anemia are responsible for diseases, and are considered hemoglobinopathies.
14.
Anemia of chronic disease, hereditary spherocytosis, hereditary hemoglobinopathies ( including some cases of thalassemia minor ) may all present with a normal RDW.
15.
In patients with diseases that reduce red blood cell lifespan, such as hemolytic anaemia or hemoglobinopathies because abnormal hemoglobin variants can interfere in the analysis.
16.
The two conditions may overlap, however, since some conditions which cause abnormalities in globin proteins ( hemoglobinopathy ) also affect their production ( thalassemia ).
17.
However, many hemoglobin variants do not cause pathology or anemia, and thus are often not classed as hemoglobinopathies, because they are not considered pathologies.
18.
In practice, fructosamine is rarely measured clinically ( even in individuals with hemoglobinopathies or other red cell disorders ) due to a number of pragmatic concerns.
19.
Differences in allele frequencies contribute to group differences in the incidence of some Ashkenazi Jewish populations ), or geographical ( hemoglobinopathies among people with ancestors who lived in malarial regions ).
20.
Some hemoglobinopathies ( and also related diseases like glucose-6-phosphate dehydrogenase deficiency ) seem to have given an evolutionary benefit, especially to heterozygotes, in areas where malaria is endemic.
