| 1. | Either hemoglobinopathy or thalassemia, or both, may cause anemia.
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| 2. | Thus, some hemoglobinopathies are also thalassemias, but most are not.
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| 3. | Hemoglobinopathies imply structural abnormalities in the globin proteins themselves.
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| 4. | It is one of the most prevalent hemoglobinopathies with 30 million people affected.
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| 5. | Certain hemoglobinopathies, the most common of which is sickle cell trait, do this.
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| 6. | Other causes of splenomegaly ( for example, Gaucher disease or hemoglobinopathies ) can also predispose to infarction.
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| 7. | The other forms of the disease require a pre-existing medical condition, usually associated with thalassemic hemoglobinopathy.
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| 8. | Some mutations in the globin chain are associated with the hemoglobinopathies, such as sickle-cell disease and thalassemia.
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| 9. | If both parents carry a hemoglobinopathy trait, the risk is 25 % for each pregnancy for an affected child.
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| 10. | Early identification of individuals with sickle cell disease and other hemoglobinopathies allows treatment to be initiated in a timely fashion.
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