It is the first approved therapy for paroxysmal nocturnal hemoglobinuria.
2.
Paroxysmal cold hemoglobinuria is treated by removing the underlying cause, such as infection.
3.
It was initially approved to treat paroxysmal nocturnal hemoglobinuria, a rare blood disorder.
4.
Red cell destruction in these acute hemolytic events is largely intravascular and therefore is associated with hemoglobinuria.
5.
Hemoglobinuria is seen due to excretion of red-blood-cell lysis byproducts via the kidneys.
6.
It is possible to use an ammonia sulphate precipitation test in order to distinguish between hemoglobinuria and myoglobinuria.
7.
The symptoms are fever and chills, sometimes with back pain and pink or red urine ( hemoglobinuria ).
8.
Most notably, deficiency of the MAC inhibitor CD59 results in an overactivity of complement and Paroxysmal nocturnal hemoglobinuria.
9.
:: : : The most dramatic disease which causes the symptoms you describe, is Paroxysmal cold hemoglobinuria.
10.
Sir Dacie is credited with characterizing the relationship between paroxysmal nocturnal hemoglobinuria and bone marrow failure syndromes like aplastic anemia.
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