Through several more biosynthetic steps, squalene is transformed into lanosterol, a direct precursor for cholesterol.
12.
In eukaryotes, lanosterol synthase is an integral monotopic protein associated with the cytosolic side of the endoplasmic reticulum.
13.
In subsequent steps DMAPP and IPP join to form geranyl pyrophosphate ( GPP ), which synthesizes the steroid lanosterol.
14.
Here, the isoprene units are joined to make squalene and folded into a set of rings to make lanosterol.
15.
These mutations prevent the azole drug from binding, while still allowing binding of the enzyme's natural substrate, lanosterol.
16.
As a member of this family, lanosterol 14 ?-demethylase is responsible for an essential step in the biosynthesis of sterols.
17.
Heme A has an isoprenoid tail, and lanosterol, the sterol precursor in animals, is derived from squalene and hence from isoprene.
18.
These distinct activities are unrelated to inhibition of the cytochrome P450 lanosterol 14 alpha-demethylase and the exact molecular targets responsible remain unidentified.
19.
It is formed when squalene is substrate of various oxidosqualene cyclases, including lanosterol synthase, which produces lanosterol, a precursor to cholesterol.
20.
It is formed when squalene is substrate of various oxidosqualene cyclases, including lanosterol synthase, which produces lanosterol, a precursor to cholesterol.
