| 11. | Dermal neurofibroma typically arise in the teenage years and are often associated with the onset of puberty.
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| 12. | A blood test for protein melanoma inhibitory activity may be used to detect the presence of neurofibromas.
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| 13. | Treating patients with extensive neurofibromas with [ a ] CO 2 laser is still the best choice.
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| 14. | However, besides pain, plexiform neurofibromas are sometimes removed due to the possibility of malignant transformation.
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| 15. | Once a plexiform neurofibroma has undergone malignant transformation, radiation and chemotherapy can be used as treatment.
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| 16. | About 10 % of plexiform neurofibromas undergo transformation into a malignant peripheral nerve sheath tumor ( MPNST ).
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| 17. | There has even been a documented case of a Schwannoma being induced from a neurofibroma due to radiation therapy.
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| 18. | Plexiform neurofibromas can grow from nerves in the skin or from more internal nerve bundles, and can be very large.
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| 19. | In a paper titled " Hypertrophic Scars After Therapy with CO 2 Laser for Treatment of Multiple Cutaneous Neurofibromas"
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| 20. | In order for the neurofibroma to develop, cells that are heterozygous for the NF1 gene must be recruited to the site.
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