But Centaur has since focused on human applications for its new class of anti-oxidants called NRTs ( for nitrone-related therapeutic ).
12.
This reaction is a 1, 3-dipolar cycloaddition, in which the nitrone acts as the 1, 3-dipole, and the alkene or alkyne as the dipolarophile.
13.
In 1991, a paper was published about the synthesis of lythranidine by William Carruthers, Peter Coggins and John B . Weston who had synthesized the compound in 11 steps using nitrone cycloaddition.
14.
The reaction rate is enhanced by water and is extremely fast with second order rate constants ranging from 12 to 32 M " 1 " s " 1, depending on the substitution of the nitrone.
15.
Diaryl-strained-cyclooctynes including dibenzylcyclooctyne ( DIBO ) have also been used to react with 1, 3-nitrones in strain-promoted alkyne-nitrone cycloadditions ( SPANC ) to yield N-alkylated isoxazolines.
16.
The "'nitrone-olefin [ 3 + 2 ] cycloaddition "'reaction is the combination of a nitrone with an alkene or alkyne to generate an isoxazoline or isoxazolidine via a [ 3 + 2 ] cycloaddition process.
17.
The "'nitrone-olefin [ 3 + 2 ] cycloaddition "'reaction is the combination of a nitrone with an alkene or alkyne to generate an isoxazoline or isoxazolidine via a [ 3 + 2 ] cycloaddition process.
18.
A dipole of this class is referred to as a "'HOMO-LUMO-controlled dipole "'or an "'ambiphilic dipole "', which includes nitrile imide, nitrone, carbonyl oxide, nitrile oxide, and azide.
19.
The applications of this reaction include labeling proteins containing serine as the first residue : the serine is oxidized to aldehyde with NaIO 4 and then converted to nitrone with p-methoxybenzenethiol, N-methylhydroxylamine and p-ansidine, and finally incubated with Cyclooctyne to give a click product.
20.
A common method for spin-trapping involves the addition of radical to a nitrone spin trap resulting in the formation of a spin adduct, a nitroxide-based persistent radical, that can be detected using EPR . The spin adduct usually yields a distinctive EPR spectrum characteristic of a particular free radical that is trapped.
