Ioflupane has a high binding affinity for presynaptic dopamine transporters ( dopaminergic neurons in the striatal region.
12.
These findings suggest that personality traits may be affected by the strength of limbic-striatal connectivity.
13.
Damage to the fronto-striatal system may underlie cognitive problems including executive function and sequencing tasks.
14.
Another area of impairment due to fronto-striatal dysfunction is in the area of emotion recognition.
15.
For example, striatal " GABAergic neurons " utilize opioid peptides or substance P as their primary cotransmitter.
16.
More of their striatal cells contained a protein called calbindin, which is known to protect neurons from damage.
17.
FMRI studies suggest that frontal-striatal brain regions are recruited for the cognitive tasks involved in sentence processing.
18.
These results suggest that striatal dopamine reuptake may occur outside of synaptic specializations once dopamine diffuses from the synaptic cleft.
19.
Additionally, oxidative stress may be responsible for loss of striatal dopamine which may contribute to pathophysiology of the disease.
20.
Separate interneurons are known to communicate with striatal spiny neurons in the presence of the somatic nervous system neurotransmitter acetylcholine.
