| 11. | The introduction of DSBs in DNA often employs the topoisomerase-like protein SPO11.
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| 12. | It is believed that eukaryotic cells do not contain DNA gyrase or topoisomerase IV.
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| 13. | However, when Topoisomerase IV alone was inhibited, decatenation was almost completely blocked.
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| 14. | Cadmium has been shown to be carcinogenic due to interactions with DNA topoisomerase II?.
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| 15. | It works by blocking the topoisomerase enzyme that is essential for cancer cells to proliferate.
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| 16. | Gyrase ( a form of topoisomerase ) relaxes and undoes the supercoiling caused by helicase.
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| 17. | Topoisomerase 1 inhibition is synthetically lethal with deficiency of expression of certain DNA repair genes.
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| 18. | In cancers, the topoisomerase II-alpha is highly expressed in highly proliferating cells.
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| 19. | Both gyrase and topoisomerase IV CTDs bend DNA, but only gyrase introduces negative supercoils.
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| 20. | It also shows an antileishmanial activity in animal models being an inhibitor of topoisomerase I.
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