| 21. | Cathepsin S is expressed by some epithelial cells.
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| 22. | M cells express the protease cathepsin E, similar to other antigen presenting cells.
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| 23. | Cathepsin D is an aspartic endo-protease that is ubiquitously distributed in lysosomes.
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| 24. | While pH optima of many lysosomal proteases are acidic, cathepsin S is an exception.
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| 25. | In contrast, cathepsin S remains stable and has a physiological role outside the lysosome.
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| 26. | In vitro, cathepsin S retains some enzyme activity in the presence of 3M urea.
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| 27. | The expression of cathepsin S can be triggered by proinflammatory factors secreted by tumor cells.
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| 28. | Cathepsin K antibodies are marketed for research into expression of this enyzme by various cells.
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| 29. | Nonetheless, these structures contain endocytic markers even small lysosomal proteins such as cathepsin D.
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| 30. | Cathepsin D is involved in CLN10.
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