Zebrafish have also been found to regenerate photoreceptor cells and retinal neurons following injury, which has been shown to be mediated by the dedifferentiation and proliferation of histone demethylation occurs at the site of the amputation, switching the zebrafish's cells to an " active ", regenerative, stem cell-like state.
22.
Cells can become anaplastic in two ways : neoplastic tumor cells can dedifferentiate to become anaplasias ( the dedifferentiation causes the cells to lose all of their normal structure / function ), or cancer stem cells can increase in their capacity to multiply ( i . e ., uncontrollable growth due to failure of differentiation ).
23.
An important pathophysiological mechanism of leukemogenesis in AML is the epigenetic induction of dedifferentiation by genetic mutations that alter the function of epigenetic enzymes, such as the DNA demethylase TET2 and the metabolic enzymes IDH1 and IDH2, which lead to the generation of a novel oncometabolite, " D "-2-hydroxyglutarate, which inhibits the activity of epigenetic enzymes such as TET2.
24.
And even if he did I'd be suspicious that the organism would turn out to be clonal from some recent'generation'of dedifferentiation, coming out of a germ cell lineage, rather than representing the full set of cells that the first medusa had to begin with . ( Since cells of an organism are supposed to be clonal to begin with, that's a picayune distinction, but the point is, if the cells are clonal from a germ cell they have had less chance to accumulate somatic mutations / cancer, but also, if the cells were able to store memories somehow then all those memories would be erased just as with a new individual ) talk ) 17 : 51, 26 December 2014 ( UTC)
