Epithelioid sarcomas typically express vimentin, cytokeratins, epithelial membrane antigen, and CD34, whereas they are usually negative for S100, desmin, and FLI-1.
22.
Desmin, titin, and other z-line proteins are involved in eccentric contractions, but their mechanism is poorly understood in comparison to crossbridge cycling in concentric contractions.
23.
In human heart failure, desmin expression is upregulated, which has been hyopthesized to be a defense mechanism in an attempt to maintain normal sarcomere alignment amidst disease pathogenesis.
24.
Desmin was first described in 1976, first purified in 1977, the gene was cloned in 1989, The function of desmin has been deduced through studies in knockout mice.
25.
Desmin was first described in 1976, first purified in 1977, the gene was cloned in 1989, The function of desmin has been deduced through studies in knockout mice.
26.
In 1980, synemin was first identified in avian smooth muscle and was initially described as an IF-associated protein due to its colocalization and copurification with desmin and vimentin.
27.
Biomechanical analyses of the consequence of the deficiencies in the cytoskeletal proteins dystrophin ( the protein deficient in Duchenne muscular dystrophy ) and desmin in isolated muscle fibres and muscle cell cultures
28.
Its size, structure, and sequence / location of protein motifs is similar to other type III IF proteins such as desmin, vimentin and glial fibrillary acidic protein ( GFAP ).
29.
It is closely related to its non-epithelial family members, vimentin, desmin, and peripherin, which are all involved in the structure and function of the cell s cytoskeleton.
30.
Other cytoskeletal proteins involved in DCM include ?-cardiac actin, desmin, and the nuclear lamins A and C . Mitochondrial deletions and mutations presumably cause DCM by altering myocardial ATP generation.
