A variety of more advanced forms of the A1c test ( e . g . some types of HPLC, immunoassay and capillary electrophoresis ) can more accurately assay A1c levels during complex hemoglobinopathies and other conditions.
22.
Anemia from lead poisoning is of special concern in Middle Eastern and South Asian countries where other forms of anemia are prevalent, including iron deficiency anemia ( from malnutrition ) and hemoglobinopathy ( sickle cell anemia, thalassemia ).
23.
Due to its relative stability compared to hemoglobin Gower 1 and hemoglobin S, it has been proposed as a subject for reactivation in the adult in cases of severe hemoglobinopathies in subjects for which the reactivation of hemoglobin F is contraindicated due to toxicity concerns.
24.
Hence, people with recent blood loss, hemolytic anemia, or genetic differences in the hemoglobin molecule ( hemoglobinopathy ) such as sickle-cell disease and other conditions, as well as those that have donated blood recently, are not suitable for this test.
25.
ISLH has also expanded its focus to include a number of sub-disciplines related to laboratory hematology, including Cellular Analysis, Flow Cytometry, Hemostasis and Thrombosis, Molecular Diagnostics, Hematology Informatics, Hemoglobinopathies, Hemolytic Anemias, Point of Care Testing and Standards and guidelines.
26.
A 2009 study, published under the mentorship of Griffin P . Rodgers, discovered that in human erythrocytes ( peripheral blood CD34 + cells ), the stem cell factor ( SCF ) induces ?-globin gene expression by regulating downstream transcription factor COUP-TFII, which can be a crucial molecular mechanism that has the potential for the development of effective pharmacologic strategies for treatment of patients with sickle cell disease or other ?-hemoglobinopathies.
