Here, the isoprene units are joined together to make squalene and then folded up and formed into a set of rings to make lanosterol.
22.
A number of early attempts to block the synthesis of cholesterol resulted in agents that inhibited late in the biosynthetic pathway between lanosterol and cholesterol.
23.
In particular, this protein catalyzes the removal of the C-14 ?-methyl group from lanosterol ( Lepesheva et al . ).
24.
Studies in which lanosterol synthase is partially inhibited have shown both a direct decrease in lanosterol formation and a decrease in HMG-CoA reductase activity.
25.
Studies in which lanosterol synthase is partially inhibited have shown both a direct decrease in lanosterol formation and a decrease in HMG-CoA reductase activity.
26.
Due to the enzyme s role in cholesterol biosynthesis, there is interest in lanosterol synthase inhibitors as potential cholesterol-reducing drugs, to complement existing statins.
27.
Disregarding some intermediate compounds ( e . g . 4-4-dimethylzymosterol ) lanosterol can be considered a precursor of zymosterol in the cholesterol synthesis pathway.
28.
Replacement of a hydrogen atom attached to carbon number 3 in the 5? isomer with a hydroxyl group results in lanosterol, the precursor of the steroids in animals.
29.
This demethylation step is regarded as the initial checkpoint in the transformation of lanosterol to other sterols that are widely used within the cell ( Lepesheva et al . ).
30.
It is the starting point for the synthesis of almost all plant steroids, making them chemically distinct from the steroids of fungi and animals which are instead produced from lanosterol.
