The megakaryocytes that give rise to platelets, synthesize EGF ( see this paper, as do macrophages.
22.
This core is surrounded by a peripheral layer of myeloid, erythroid and megakaryocyte progenitor cells and their progeny.
23.
Thrombopoietin, upon release, binds to its receptor, c-mpl, found on megakaryocyte progenitor cells.
24.
Testosterone also regulates the population of thromboxane A 2 receptors on megakaryocytes and platelets and hence platelet aggregation in humans.
25.
It stimulates the production and differentiation of megakaryocytes, the bone marrow cells that bud off large numbers of platelets.
26.
PU . 1 for Erythroid-megakaryocyte lineage and GATA-1, which leads to a lymphoid-primed multipotent progenitor.
27.
It is expressed exclusively in megakaryocytes and platelets in humans and appears to play an important role in the formation of platelets.
28.
TPO-R deficient mice were severely thrombocytopenic, emphasizing the important role of CD110 and thrombopoietin in megakaryocyte and platelet formation.
29.
The 206 amino acid precursor of GPIb beta is synthesized from a 1.0 kb mRNA expressed in plateletes and megakaryocytes.
30.
The protein encoded by this gene is a humoral growth factor necessary for megakaryocyte proliferation and maturation, as well as for thrombopoiesis.
