| 21. | The osteoclasts are multi-nucleated cells that contain numerous mitochondria and lysosomes.
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| 22. | Direct effects of chronic alcoholism are apparent in osteoblasts, osteoclasts and osteocytes.
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| 23. | At the same time, it has a direct effect on osteoclast activity.
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| 24. | TRAP substrates, which bind to osteoclasts when phosphorylated.
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| 25. | Occasional osteoclast-like giant multinucleated cells are encountered particularly at the periphery.
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| 26. | Bone continuously undergoes remodeling by actions of bone resorbing osteoclasts and bone forming osteoblasts.
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| 27. | Osteoclasts move in to reabsorb dead bone ends and other necrotic tissue are removed.
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| 28. | Once activated, osteoclasts move to areas of microfracture in the bone by chemotaxis.
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| 29. | Osteoclasts are usually found grouped in the small pits on bone surfaces called lacunae.
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| 30. | This reabsorption process can sometimes take up to weeks for the osteoclast to complete.
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