The insulin would be added to the protamine, but the solution would have to be brought to pH 7 for injection.
22.
Protamine is used in cardiac surgery, vascular surgery, and interventional radiology procedures to neutralize the anti-clotting effects of heparin.
23.
For example, Humulin N is combined with protamine to extend the time-activity profile of Humulin R for an extended period.
24.
The H1FNT protein is essential for nuclear formation in spermatozoa, and is involved in the replacement of histones with protamines during spermiogenesis.
25.
Studies in animals and in vitro studies have demonstrated that protamine neutralizes the antithrombin activity of LMWHs, normalizing the aPTT and thrombin time.
26.
Heparin is the most commonly used anticoagulant in hemodialysis, as it is generally well tolerated and can be quickly reversed with protamine sulfate.
27.
NovoLog Mix 70 / 30 is a product marketed by Novo Nordisk which contains 30 % insulin aspart and 70 % insulin aspart protamine.
28.
In clinical situations in which the antithrombotic effect of LMWHs needs to be neutralized, protamine is used to neutralize heparin by binding to it.
29.
It has been used to reverse pulmonary hypertension caused by protamine ( which in turn was administered to reverse the effects of heparin overdose ).
30.
Furthermore, human peptidases may degrade protamine at different rates, thus further tests are required to determine protamine s ability to prevent obesity in humans.
