It catalyzes the N ( 1 )-acetylation of spermidine and spermine and, by the successive activity of polyamine oxidase, spermine can be converted to spermidine and spermidine to putrescine.
22.
""'S "-Adenosylmethioninamine "'( "'decarboxylated substrate that is involved in the biosynthesis of polyamines including spermidine, spermine, and thermospermine.
23.
9-Aminoacridine, 9-tetrahydroaminoacridine, N1-dansyl-spermine, N1-dansyl-spermidine, and pentamidine have been shown to act as antagonists of ? 2-containing receptors.
24.
In 1971, Kim " et al . " achieved another breakthrough, producing crystals of yeast tRNA PHE that diffracted to 2-3 �ngstr�m resolutions by using spermine, a naturally occurring polyamine, which bound to and stabilized the tRNA.
25.
The name " spermin " was first used by the German chemists Ladenburg and Abel in 1888, and the correct structure of spermine was not finally established until 1926, simultaneously in England ( by Dudley, Rosenheim, and Starling ) and Germany ( by Wrede et al . ).
26.
Spermidine is known to regulate plant growth, assisting the " in vitro " process of transcribing RNA, and inhibition of NOS . Also, spermidine is a precursor to other polyamines, such as spermine and thermospermine, some of which contribute to tolerance against drought and salinity in plants.
27.
The STRING-Known and Predicted Protein Interaction database was used to determine proteins that may be interacting and the following proteins were candidates for interaction : somatostatin ( SST ), somatostatin receptor 2 ( SSTR2 ) as well as a variety of other somatostatin receptors, spermine synthase ( SMS ), and TMEM132C . All of the somatostatin related proteins are involved in the inhibition of hormones.
28.
In 1971, Kim " et al . " achieved another breakthrough, producing crystals of yeast tRNA PHE that diffracted to 2-3 �ngstr�m resolutions by using spermine, a naturally occurring polyamine, which bound to and stabilized the tRNA . Despite having suitable crystals, however, the structure of tRNA PHE was not immediately solved at high resolution; rather it took pioneering work in the use of heavy metal derivatives and a good deal more time to produce a high-quality density map of the entire molecule.
