| 1. | Primary examples are putrescine, cadaverine, spermidine, and spermine.
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| 2. | Spermine is the chemical primarily responsible for the characteristic odor of semen.
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| 3. | Its activity is inhibited by spermine, sphingosine, and several phospholipids.
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| 4. | Spermidine is a precursor to further polyamines, such as spermine and its structural isomer thermospermine.
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| 5. | For comparison the similar substance spermine, found in semen, is over 3 times as toxic.
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| 6. | "' Spermine "'is a polyamine involved in cellular metabolism found in all bacteria.
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| 7. | Crystals of spermine phosphate were first described in 1678, in human semen, by Antonie van Leeuwenhoek.
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| 8. | Agmatinase hydrolyses agmatine to putrescine, the precursor for the biosynthesis of higher polyamines, spermidine and spermine.
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| 9. | Basic amines such as putrescine, spermine, spermidine and cadaverine are responsible for the smell and flavor of semen.
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| 10. | :spermine + O 2 + H 2 O \ rightleftharpoons spermidine + 3-aminopropanal + H 2 O 2
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