| 21. | A heme group coordinated to a cysteine residue from the enzyme, thromboxane synthase, is involved in the mechanism.
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| 22. | "' Ozagrel "'( INN ) is an antiplatelet agent working as a thromboxane A2 synthesis inhibitor.
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| 23. | Unlike thromboxane synthase inhibitors such as ozagrel, seratrodast does not affect thrombus formation, time to occlusion and bleeding time.
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| 24. | These " Sticky platelets " secrete several chemicals, including thromboxane A2 that stimulate vasoconstriction, reducing blood flow at the site.
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| 25. | The human thromboxane A ( TXA ) synthase is a 60 kDa protein with 533 amino acids and a heme prosthetic group.
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| 26. | It also sometimes is used to reduce platelet aggregation by inhibiting degranulation of platelets which reduces the release of ADP and thromboxane.
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| 27. | Aspirin blocks an enzyme, cyclo-oxygenase, that is involved in producing thromboxane, a substance that induces platelets to clump.
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| 28. | Aspirin works by blocking the formation of thromboxane A2, a chemical in the body that makes platelets sticky and promotes blood clotting.
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| 29. | However the serotonin and the thromboxane A2 cause more contraction of the smooth muscle cells and as a result contractions outweigh the relaxations.
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| 30. | In catalyzing the synthesis of thromboxanes, TXA synthase is involved in a flux pathway that can modulate the amount of thromboxane produced.
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