Each thyroglobulin molecule contains approximately 100-120 tyrosine residues, a small number of which ( < 20 ) are subject to iodination catalysed by thyroperoxidase.
22.
Hence, thyroglobulin levels in the blood are mainly used as a tumor marker for certain kinds of thyroid cancer ( particularly papillary or follicular thyroid cancer ).
23.
IL-10 produced by T regulatory cells was important in suppressing the mouse thyroglobulin specific T cell response and therefore protecting against Experimental autoimmune thyroiditis in mice.
24.
The protein is a precursor of the thyroid hormones; these are produced when thyroglobulin's tyrosine residues are combined with iodine and the protein is subsequently cleaved.
25.
Thyroglobulin will also be measurable in a healthy thyroid, and will increase with inflammation, and may also be used to measure the success of thyroid removal or ablation.
26.
Mouse models of autoimmune thyroiditis showed that a semi-mature phenotype of dendritic cells is maintained after mouse thyroglobulin immunization in GM-CSF treated but not control mice.
27.
Genes that are believed to be involved include those for thyroglobulin, thyrotropin receptor, protein tyrosine phosphatase nonreceptor type 22 and cytotoxic T-lymphocyte associated antigen 4 among others.
28.
Each thyroglobulin molecule contains approximately 100-120 tyrosine residues, but only a small number ( 20 ) of these are subject to iodination by thyroperoxidase in the follicular colloid.
29.
Finally, office based thyroid blood hormone studies, such as T4, T3, TSH, TPO thyroid antibodies, and cancer markers thyroglobulin, TG and Calcitonin, CT.
30.
It is produced as the precursor thyroglobulin ( this is " not " the same as TBG ), which is cleaved by enzymes to produce active T 4.
