| 1. | Thyroglobulin is not produced by medullary or anaplastic thyroid carcinoma.
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| 2. | Thyroglobulin protein accounts for approximately half of the protein content of the thyroid gland.
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| 3. | If successful, thyroglobulin should be undetectable.
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| 4. | Iodine in the bloodstream is taken up by the gland and incorporated into thyroglobulin molecules.
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| 5. | The thyroglobulin protein accounts for approximately half of the protein content of the thyroid gland.
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| 6. | However, the breakdown of thyroglobulin produces 6-7 fold more iodinated tyrosines than thyroid hormone.
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| 7. | A subsequent elevation of the thyroglobulin level is an indication of recurrence of papillary or follicular thyroid carcinoma.
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| 8. | Within the thyroid follicular cell, thyroglobulin is hydrolyzed to form thyroid hormones and mono-and diiodotyrosine.
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| 9. | When the follicular cells are stimulated by thyroid-stimulating hormone, the follicular cells reabsorb thyroglobulin from the follicular space.
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| 10. | Lastly, antibodies against components of the thyroid, particularly anti-TPO and anti-thyroglobulin, can be measured.
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