| 21. | Topotecan inhibits topoisomerase I restoring UBE3A levels to wild-type range in cultured mince neurons.
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| 22. | Many topoisomerase enzymes sense supercoiling and either generate or dissipate it as they change DNA topology.
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| 23. | The proper function of RecQ helicases requires the specific interaction with topoisomerase III ( Top 3 ).
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| 24. | The study suggested that the topoisomerase inhibitors have the potential to produce a normally functioning UBE3A protein.
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| 25. | Additionally, topoisomerase II has been implicated in the regulation of Aurora B localization and enzymatic activity.
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| 26. | Topoisomerase I is an enzyme that mediates reversible single-strand breaks in DNA during DNA replication.
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| 27. | Some chemotherapy drugs called topoisomerase inhibitors work by interfering with mammalian-type eukaryotic topoisomerases in cancer cells.
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| 28. | EGCG, genistein, quercetin, resveratrol ) possess strong topoisomerase inhibitory properties affecting both types of enzymes.
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| 29. | Topoisomerase IV in " E . coli " unlinks or decatenates the two circular DNA duplexes.
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| 30. | They are also referred to as anti-DNA topoisomerase I antibody ( anti-topo I ).
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