| 31. | The optimum pH for cathepsin D in vitro is 4.5-5.0.
|
| 32. | Jones'dissertation research involved the catalytic properties of cathepsin C, a type of protease.
|
| 33. | The list of proposed cathepsin S substrates includes laminin, fibronectin elastin, osteocalcin and some collagens.
|
| 34. | For instance, cleavage of laminin-5 by cathepsin S leads to generation of proangiogenic peptides.
|
| 35. | That the expression of Cathepsin K is characteristic for some cancers and not others has been documented.
|
| 36. | Cathepsin-D is an aspartic protease that depends critically on protonation of its active site Asp residue.
|
| 37. | Cathepsin D ( an aspartyl protease ) appears to cleave a variety of substrates such as fibronectin and laminin.
|
| 38. | Cathepsin S is expressed by antigen presenting cells including macrophages, B-lymphocytes, dendritic cells and microglia.
|
| 39. | Cathepsin S plays an active role in blood vessels permeability and angiogenesis due to its elastolytic and collagenolytic activities.
|
| 40. | Knock out of cathepsin L in mice exhibited impaired blood flow restoration in ischemic limbs, indicating impaired neovascularization.
|
