Aurora B targets a number of proteins that localize to the cleavage furrow, including the type-III intermediate filament proteins vimentin, desmin, and glial fibrillary acidic protein ( GFAP ).
32.
Keratin filaments in epithelial cells link to desmosomes ( desmosomes connect the cytoskeleton together ) through plakoglobin, desmoplakin, desmogleins, and desmocollins; desmin filaments are connected in a similar way in heart muscle cells.
33.
There is some evidence that desmin may also connect the sarcomere to the extracellular matrix ( ECM ) through desmosomes which could be important in signalling between the ECM and the sarcomere which could regulate muscle contraction and movement.
34.
The smooth muscle like cells of AMLs are morphologically and immunohistochemically similar to LAM cells, including reactivity with antibodies directed against actin, desmin, vimentin, and HMB-45 as well as estrogen and progesterone receptors.
35.
These binding partners suggest that syncoilin acts as a mechanical " linker " between the sarcomere Z-disk ( where desmin is localized ) and the dystrophin-associated protein complex ( where ?-dystrobrevin is localized ).
36.
Sequence analysis showed that human desmuslin was 32 % identical and 11 % similar to the amino acid sequence of chicken synemin, while the IF proteins vimentin and desmin are more than 80 % identical across the same species.
37.
FRCs also produce components of extracellular matrix, such as ER-TR7, fibrilin, laminin, fibronectin and intracellular components such as desmin and ?-actin smooth muscle that may influence the formation of the reticular fiber network.
38.
In adult desmin-null mice, hearts from 10 wk-old animals showed drastic alterations in muscle architecture, including a misalignment of myofibrils and disorganization and swelling of mitochondria; findings that were more severe in cardiac relative to skeletal muscle.
39.
It localizes at the Z-disk and has been shown to bind to ?-dystrobrevin, ?-actinin, and desmin to act as a mechanical linker in transmitting force laterally throughout the tissue, especially between the contractile myofibrils and extracellular matrix.
40.
An example of a WACA-proteins, which are mostly found in prokaryotes, is MinD . Examples for intermediate filaments, which have almost exclusively been found in animals ( i . e . eukaryotes ) are the lamins, keratins, vimentin, neurofilaments, desmin.
