| 31. | On July 10, 2007 Manhattan Pharmaceuticals announced that its phase 2a studies for oral oleoyl-estrone failed.
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| 32. | About 15 % of orally administered estradiol is converted into estrone and 65 % is converted into estrone sulfate.
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| 33. | About 15 % of orally administered estradiol is converted into estrone and 65 % is converted into estrone sulfate.
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| 34. | Bioidentical estradiol ( estrogen ) when taken orally is converted in the liver to estrone, a weaker bioidentical estrogen.
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| 35. | This is significant because less benzestrol could be used to produce the same effect as estrone in increasing estrogen production.
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| 36. | Then, placental 17?-hydroxysteroid dehydrogenase interconverts estrone and estradiol and the two hormones are secreted into the maternal circulation.
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| 37. | These concentrations of estradiol and estrone are comparable to those observed with 1 and 2 mg / day oral micronized estradiol.
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| 38. | In the diagram, Part A represents the successful conversion of androstenedione and testosterone into estrone and estradiol in the liver.
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| 39. | E2S can also be metabolized into estrone sulfate ( E1S ), which in turn can be converted into estrone and estradiol.
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| 40. | E2S can also be metabolized into estrone sulfate ( E1S ), which in turn can be converted into estrone and estradiol.
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