| 31. | "' Vorozole "'is an imidazole based competitive inhibitor of the aromatase enzyme.
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| 32. | As a result, imidazole engineering has been suggested as a means to specifically inhibit NO dioxygenases.
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| 33. | But the imidazole and pyridine lone pairs also look good for accounting for some of those pKas.
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| 34. | Also, calculations show that the C4 hydrogen is less acidic than the C2 hydrogen of imidazole.
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| 35. | The difference between the imidazoles and the triazoles involves the mechanism of inhibition of the cytochrome P450 enzyme.
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| 36. | Like other imidazole antifungals, sertaconazole blocks the synthesis of ergosterol by inhibiting the 14?-demethylase enzyme.
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| 37. | The distal imidazole is not bonded to the iron but is available to interact with the substrate O 2.
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| 38. | Glyoxal is a valuable building block in organic synthesis, especially in the synthesis of heterocycles such as imidazoles.
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| 39. | It also suggests that the use of an imidazole-imidazolium conversion controls access to the allosteric B site.
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| 40. | 1-Methylimidazole is also the precursor for the synthesis of the methylimidazole monomer of pyrrole-imidazole polyamides.
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