The gyrase inhibition occurs in both supercoiling and relaxing activities of the DNA gyrase, and the study concluded that the inhibition activity was able to proceed, unchanged, in the presence of the racemase substrate.
32.
It is an important object of study in knot theory, algebraic topology, and differential geometry, and has numerous applications in mathematics and science, including quantum mechanics, electromagnetism, and the study of DNA supercoiling.
33.
In eukaryotes, DNA supercoiling exists on many levels of both plectonemic and solenoidal supercoils, with the solenoidal supercoiling proving most effective in compacting the DNA . Solenoidal supercoiling is achieved with histones to form a 10 nm fiber.
34.
In eukaryotes, DNA supercoiling exists on many levels of both plectonemic and solenoidal supercoils, with the solenoidal supercoiling proving most effective in compacting the DNA . Solenoidal supercoiling is achieved with histones to form a 10 nm fiber.
35.
In eukaryotes, DNA supercoiling exists on many levels of both plectonemic and solenoidal supercoils, with the solenoidal supercoiling proving most effective in compacting the DNA . Solenoidal supercoiling is achieved with histones to form a 10 nm fiber.
36.
SR proteins can become hypophosphorylated during elongation decreasing their affinity for RNA polymerase II causing SR proteins to move to Topo I . When Topo I complexes with SF2 / ASF, it can no longer undo the supercoiling of DNA causing elongation to pause.
37.
These proteins include helicases, which unwind the double-stranded DNA molecule to facilitate access to it, RNA polymerases, which bind to the DNA promoter to synthesize the growing RNA molecule, topoisomerases, which change the amount of supercoiling in DNA, helping it wind and unwind, as well as a large variety of transcription factors that regulate expression.
38.
SR proteins can also stabilize DNA during transcription through an interaction with Topoisomerase I . When Topoisomerase I, Topo I, reduces supercoiling caused by transcription when it is bound to DNA . When Topo I is not bound to DNA it can phosphorylate the SR protein SF2 / ASF . Topo I and SF2 / ASF interact when SF2 / ASF is hypophosphorylated during transcription elongation.
39.
There are, of course, a great many little oddities that you could mention in regard to it-artificial nanoscale engineering of complex structures, sequence-specific reception of radio-frequency or terahertz signals, the ability of supercoiling to convert overall torsion of the structure into a separation of strands, or vice versa, the ability to nick the structure so that topoisomerase I can release said supercoiling, under control, the ability of PCNA and other proteins to clamp onto the strand and run it like a more or less smooth " string " through holes in a protein complex . . . there must be thousands of specific relevant significances . talk ) 03 : 40, 26 August 2012 ( UTC)
40.
There are, of course, a great many little oddities that you could mention in regard to it-artificial nanoscale engineering of complex structures, sequence-specific reception of radio-frequency or terahertz signals, the ability of supercoiling to convert overall torsion of the structure into a separation of strands, or vice versa, the ability to nick the structure so that topoisomerase I can release said supercoiling, under control, the ability of PCNA and other proteins to clamp onto the strand and run it like a more or less smooth " string " through holes in a protein complex . . . there must be thousands of specific relevant significances . talk ) 03 : 40, 26 August 2012 ( UTC)
