Greater activation also results in increased expression of myogenic basic helix-loop-helix transcription factors MyoD, myogenin, and MRF4-all responsible for the induction of myocyte-specific genes.
42.
An additional study showed that myocytes expressing a dominant negative N-cadherin mutant showed significant abnormalities in myocyte distribution and migration towards the endocardium, resulting in defects in trabecular formation within the myocardium.
43.
A few of these defects include myocyte maturation and proliferation defects that cause a thin ventricular myocardial compact zone, non-separation of the pulmonary artery and aorta, and cardiomyocyte proliferation increase and defective differentiation.
44.
HCM is most commonly due to a mutation in one of nine sarcomeric genes that results in a mutated protein in the sarcomere, the primary component of the myocyte ( the muscle cell of the heart ).
45.
In cardiovascular disease, Cx43 ( connexin 43 ), a subunit of a connexon, is a general protein of the gap junction stimulating cardio myocyte muscle cells of intercalated discs facilitating synchronized beating of the heart.
46.
The name of the histopathologic finding comes from the appearance under the microscope; contraction bands are thick intensely eosinophilic staining bands ( typically 4-5 micrometres wide ) that span the short axis of the myocyte.
47.
Two proteins are essential for the regulation of GLUT-4 expression at a transcriptional level myocyte enhancer factor 2 ( nucleus, as well as increase the binding of both to the GLUT-4 promoter region.
48.
To do this, it enhances the activity of transcription factors like nuclear respiratory factor 1 ( NRF-1 ), myocyte enhancer factor 2 ( MEF2 ), host cell factor ( HCF ), and others.
49.
During cardiomyocyte maturation in new born mouse heart, p38? MAPK activity can regulate myocyte cytokinesis and promote cell cycle exit . while inhibition of p38 MAPK activity leads to induction of mitosis in both adult and fetal cardiomyocyte.
50.
In the heart Foxp1 has 3 vital roles, these include the regulation of cardiac myocyte maturation and proliferation, outflow tract separation of the pulmonary artery and aorta, and expression of knockout embryos display severe defects in cardiac morphogenesis.
