| 41. | Production of thrombin via massive bleeding causes the uterus to contract and leads to DIC.
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| 42. | The cellular effects of thrombin are mediated by protease-activated receptors ( PARs ).
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| 43. | It mediates thrombin-triggered phosphoinositide hydrolysis and is expressed in a variety of tissues.
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| 44. | F2RL3 is activated by thrombin and trypsin.
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| 45. | The highly negative charge density of heparin contributes to its very strong electrostatic interaction with thrombin.
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| 46. | The excess thrombin cleaves fibrinogen, which ultimately leaves behind multiple fibrin clots in the circulation.
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| 47. | It does not act on thrombin, trypsin or chymotrypsin and does not express fibrinolytic activity.
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| 48. | Other proteases also activate Factor Va, but this cleavage is primarily carried out by thrombin.
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| 49. | Thrombin also promotes further thrombin generation, and activates platelets, stimulating aggregation and granule release.
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| 50. | Thrombin also promotes further thrombin generation, and activates platelets, stimulating aggregation and granule release.
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