| 1. | Direct thrombin inhibitors provides an excellent example of negative allosteric modulation.
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| 2. | Thrombin also promotes secondary fibrin-reinforcement of the platelet plug.
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| 3. | Each molecule of Factor Xa can generate 1000 molecules of thrombin.
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| 4. | It therefore remains active and increases the rate of thrombin generation.
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| 5. | Thrombin is a potent platelet activator, acting through Gq and G12.
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| 6. | Excess circulating thrombin results from the excess activation of the coagulation cascade.
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| 7. | Recombinant thrombin is available as a powder for reconstitution into aqueous solution.
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| 8. | It functions as an inhibitor of coagulation by inhibiting thrombin.
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| 9. | Inactivation of Factor V a thus practically halts the production of thrombin.
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| 10. | Several other direct thrombin inhibitors are derived chemically from hirudin.
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