ceruloplasmin वाक्य
उदाहरण वाक्य
मोबाइल
- ATP7B directs copper to plasma ceruloplasmin or to biliary excretion in concert with a newly discovered chaperone, Murr1, the protein missing in canine copper toxicosis.
- The disease involves poor incorporation of copper into ceruloplasmin and impaired biliary copper excretion and is usually induced by mutations impairing the function of the Wilson copper ATPase.
- Copper accumulates in the liver tissue; ceruloplasmin is still secreted, but in a form that lacks copper ( termed apoceruloplasmin ) and is rapidly degraded in the bloodstream.
- Substances that may impart a greenish hue to one's skin include biliverdin, the green pigment in bile, and ceruloplasmin, a protein that carries copper ions in chelation.
- Mutations in the ceruloplasmin gene ( " CP " ), which are very rare, can lead to the genetic disease aceruloplasminemia, characterized by hyperferritinemia with iron overload.
- Ceruloplasmin is also an acute-phase protein produced by monocytes, and its plasma concentration can double during multiple inflammatory conditions through increased Cp production by monocytic cells after stimulation by IFN-gamma.
- Copper is an integral part of the antioxidant enzyme, copper-zinc superoxide dismutase ( Cu, Zn-SOD ), and has a role in iron homeostasis as a cofactor in ceruloplasmin.
- Harbour developed a keen interest in research during his undergraduate years at Texas A & M, where he studied the function of the copper protein ceruloplasmin in the laboratory of Dr . Edward Harris.
- Apoceruloplasmin is largely degraded intracellularly in the hepatocyte and the small amount that is released has a short circulation half life of 5 hours as compared to the 5.5 days for the holo-ceruloplasmin.
- They demonstrated that recombinant human hephaestin ( rhHp ) bound copper ( determined by inductively coupled plasma mass spectrometry ) and exhibited an absorption maximum at ~ 610 nm consistent with other blue multicopper oxidases such as ceruloplasmin.
- Comparative models of hephaestin's structure have been created using established crystallographic data from ceruloplasmin, and these studies suggest that many of the structural features important in the enzymatic function of the latter are also conserved in the former.
- In a study by Howell et al . patients were located and studied by means of complete histories and physical examinations, analyses of serum trace metals, ceruloplasmin concentration, urine and serum amino acids, and routine metabolic urine screens.
- While hephaestin shares 50 % amino acid sequence identity with its serum homologue ceruloplasmin, the hephaestin protein includes an additional 86 amino acids at the C-terminus, which code for a single transmembrane domain and a short cytoplasmic tail.
- The "'gamma interferon inhibitor of translation element "'or "'GAIT element "'is a cis-acting RNA element located in the 3'- UTR of the ceruloplasmin ( Cp ) mRNA.
- Liver cells also carry the CMT1 protein, and metallothionein and ATOX1 bind it inside the cell, but here it is ATP7B that links copper to ceruloplasmin and releases it into the bloodstream, as well as removing excess copper by secreting it into bile.
- Ceruloplasmin exhibits oxidase activity, which is associated with possible oxidation of Fe ( II ) into Fe ( III ), therefore assisting in its transport in the blood plasma in association with transferrin, which can carry iron only in the Fe ( III ) state.
- His work in the area of human genetics and liver disease led him to define the genetic nature of Wilson's Disease, which affects the liver and brain, and showed that the disease was associated with a deficiency in the blood of ceruloplasmin, a copper-binding protein.
- There is no totally reliable test for Wilson's disease, but levels of ceruloplasmin and copper in the blood, as well of the amount of copper excreted in urine during a 24-hour period, are together used to form an impression of the amount of copper in the body.
- Ceruloplasmin exhibits a copper-dependent oxidase activity, which is associated with possible oxidation of Fe 2 + ( ferrous iron ) into Fe 3 + ( ferric iron ), therefore assisting in its transport in the plasma in association with transferrin, which can carry iron only in the ferric state.
- It is not clear why Wilson's disease causes hemolysis, but various lines of evidence suggest that a high level of free ( non-ceruloplasmin bound ) copper has a direct effect on either oxidation of hemoglobin, inhibition of energy-supplying enzymes in the red blood cell, or direct damage to the cell membrane.
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