desmin वाक्य
उदाहरण वाक्य
मोबाइल
- Epithelioid sarcomas typically express vimentin, cytokeratins, epithelial membrane antigen, and CD34, whereas they are usually negative for S100, desmin, and FLI-1.
- Desmin, titin, and other z-line proteins are involved in eccentric contractions, but their mechanism is poorly understood in comparison to crossbridge cycling in concentric contractions.
- In human heart failure, desmin expression is upregulated, which has been hyopthesized to be a defense mechanism in an attempt to maintain normal sarcomere alignment amidst disease pathogenesis.
- Desmin was first described in 1976, first purified in 1977, the gene was cloned in 1989, The function of desmin has been deduced through studies in knockout mice.
- Desmin was first described in 1976, first purified in 1977, the gene was cloned in 1989, The function of desmin has been deduced through studies in knockout mice.
- In 1980, synemin was first identified in avian smooth muscle and was initially described as an IF-associated protein due to its colocalization and copurification with desmin and vimentin.
- Biomechanical analyses of the consequence of the deficiencies in the cytoskeletal proteins dystrophin ( the protein deficient in Duchenne muscular dystrophy ) and desmin in isolated muscle fibres and muscle cell cultures
- Its size, structure, and sequence / location of protein motifs is similar to other type III IF proteins such as desmin, vimentin and glial fibrillary acidic protein ( GFAP ).
- It is closely related to its non-epithelial family members, vimentin, desmin, and peripherin, which are all involved in the structure and function of the cell s cytoskeleton.
- Other cytoskeletal proteins involved in DCM include ?-cardiac actin, desmin, and the nuclear lamins A and C . Mitochondrial deletions and mutations presumably cause DCM by altering myocardial ATP generation.
- Aurora B targets a number of proteins that localize to the cleavage furrow, including the type-III intermediate filament proteins vimentin, desmin, and glial fibrillary acidic protein ( GFAP ).
- Keratin filaments in epithelial cells link to desmosomes ( desmosomes connect the cytoskeleton together ) through plakoglobin, desmoplakin, desmogleins, and desmocollins; desmin filaments are connected in a similar way in heart muscle cells.
- There is some evidence that desmin may also connect the sarcomere to the extracellular matrix ( ECM ) through desmosomes which could be important in signalling between the ECM and the sarcomere which could regulate muscle contraction and movement.
- The smooth muscle like cells of AMLs are morphologically and immunohistochemically similar to LAM cells, including reactivity with antibodies directed against actin, desmin, vimentin, and HMB-45 as well as estrogen and progesterone receptors.
- These binding partners suggest that syncoilin acts as a mechanical " linker " between the sarcomere Z-disk ( where desmin is localized ) and the dystrophin-associated protein complex ( where ?-dystrobrevin is localized ).
- Sequence analysis showed that human desmuslin was 32 % identical and 11 % similar to the amino acid sequence of chicken synemin, while the IF proteins vimentin and desmin are more than 80 % identical across the same species.
- FRCs also produce components of extracellular matrix, such as ER-TR7, fibrilin, laminin, fibronectin and intracellular components such as desmin and ?-actin smooth muscle that may influence the formation of the reticular fiber network.
- In adult desmin-null mice, hearts from 10 wk-old animals showed drastic alterations in muscle architecture, including a misalignment of myofibrils and disorganization and swelling of mitochondria; findings that were more severe in cardiac relative to skeletal muscle.
- It localizes at the Z-disk and has been shown to bind to ?-dystrobrevin, ?-actinin, and desmin to act as a mechanical linker in transmitting force laterally throughout the tissue, especially between the contractile myofibrils and extracellular matrix.
- An example of a WACA-proteins, which are mostly found in prokaryotes, is MinD . Examples for intermediate filaments, which have almost exclusively been found in animals ( i . e . eukaryotes ) are the lamins, keratins, vimentin, neurofilaments, desmin.
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