gramicidin वाक्य
उदाहरण वाक्य
मोबाइल
- Gramicidin B makes up 6 % of Gramicidin D while Gramicidin A and C make up 80 % and 14 % respectively.
- Gramicidin B makes up 6 % of Gramicidin D while Gramicidin A and C make up 80 % and 14 % respectively.
- This is a common mechanism exploited by natural and artificial biocides, including the ion channels gramicidin and amphotericin ( a fungicide ).
- Inspired by gramicidin, this molecule was designed to be a barrel-shaped entity spanning a single leaflet of a Mechanism ).
- An ion channel switch ( ICS ) biosensor can be created using gramicidin, a dimeric peptide channel, in a tethered bilayer membrane.
- He asked Bumstead, " Wouldn't it be wonderful if we had something like this gramicidin mentioned in the Reader's Digest ?"
- In collaborative work with Mark Akeson, a post-doctoral student at the time, the two established methods for monitoring proton permeation through ion channels such as gramicidin.
- "' Gramicidin B "'is part of the collective Gramicidin D that is an antibiotic obtained from a soil microbe-" Bacillus brevis ".
- "' Gramicidin B "'is part of the collective Gramicidin D that is an antibiotic obtained from a soil microbe-" Bacillus brevis ".
- Florey credited Dubos with pioneering the approach of deliberately and systematically searching for antibacterial compounds, which had led to the discovery of gramicidin and had revived Florey's research in penicillin.
- Topical use of 0.1 % propamidine isethionate ( Brolene ) plus neomycin-polymyxin B-gramicidin ophthalmic solution has been a successful approach; keratoplasty is often necessary in severe infections.
- In general, gramicidin channels are completely selective for monovalent cations and the single-channel conductances for the alkali cations are ranked in the same order as the aqueous mobilities of these ions.
- During his doctoral studies, Schmidt took part in structural studies of biologically important molecules, focusing on the structure of the antibacterial natural peptide Gramicidin S using the method of X-ray crystallography.
- While semi-synthetic ion channels, often based on modified peptidic channels like gramicidin, had been prepared since the 1970s, the first attempt to prepare a synthetic ion channel was made in 1982 using a substituted ?-cyclodextrin.
- In 1939, coinciding with the start of World War II, Rene Dubos reported the discovery of the first naturally derived antibiotic, tyrothricin, a compound of 20 % gramicidin and 80 % tyrocidine, from " B . brevis ."
- In three major studies, David Baker and co-workers " de novo " designed enzymes for the nonribosomal peptide synthetase that produces Gramicidin S, from its natural substrate phenylalanine to other noncognate substrates including charged amino acids; the redesigned enzymes had activities close to those of the wild-type.
- By 1947, Martin, Synge and their collaborators had applied this method ( along with Fred Sanger's reagent for identifying N-terminal residues ) to determine the pentapeptide sequence of Gramicidin S . These and related paper chromatography methods were also foundational to Fred Sanger's effort to determine the amino acid sequence of insulin.
- By contrast with the nonribosomal peptide synthetases that produces some cyclic peptides like gramicidin S, SICLOPPS offers the advantage that the peptides'structure can be encoded by DNA in a simple manner according to the genetic code, but for this reason it imposes limitations on the types of amino acids incorporated that are comparable to those that apply to ordinary proteins.
- In 1939, at Oxford University, seeking an alternative to sulfa drugs, Howard Florey developed Fleming's penicillin into the first systemic antibiotic drug, penicillin G . ( Gramicidin, developed by Ren?Dubos at Rockefeller Institute in 1939, was the first antibiotic, yet its toxicity restricted it to topical use . ) After World War II, Cornelius P . Rhoads introduced the chemotherapeutic approach to cancer treatment.
- In 1989 he paid tribute to Dubos on the 50th anniversary of Dubos s discovery of the antibiotic gramicidin by organizing a symposium on Launching the Antibiotic Era . At the event, he spoke of the importance of supporting young investigators and global research, the opportunities afforded single investigators working in small laboratories, the efficacy of personal involvement at the bedside, and a moral climate that led to patents for the general good .
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