gyrase वाक्य
उदाहरण वाक्य
मोबाइल
- Fourth-generation fluoroquinolones act at DNA gyrase and topoisomerase IV . This dual action slows development of resistance.
- In addition, DNA gyrase is needed to relieve the topological stress created by the action of DnaB helicase.
- Nalidixic acid and related antibiotics inhibit a subunit of DNA gyrase and topoisomerase IV and induce formation of cleavage complexes.
- Consequently, a different site of MurI, distant from its active site, is involved in interacting with gyrase.
- The unique ability of gyrase to introduce negative supercoils into DNA is what allows bacterial DNA to have free negative supercoils.
- DNA gyrase has two subunits, which in turn have two subunits each, i . e . 2A and 2B subunits.
- While topoisomerase IV does relax positive supercoils like DNA gyrase, it does not introduce further negative supercoiling like the latter enzyme.
- For gyrase, the structure has a substantial hole in the middle, which is presumed to accommodate the T-segment.
- This was shown by the inclusion of the racemase substrate L-glutamate in an assay with the separated gyrase inhibition site.
- Dosages 12 20 mg / kg orally administered for five to ten days . The antibiotic works by inhibiting the enzyme DNA gyrase.
- It also inhibits the nicking-closing activity on the subunit of DNA gyrase that releases the positive binding stress on the supercoiled DNA.
- Topoisomerases such as DNA gyrase ( Type II Topoisomerase ) play a role in relieving some of the stress during DNA / RNA synthesis.
- DNA gyrase preliminary role is to introduce negative super coils into DNA, thereby relaxing positive supercoils that come into play during DNA replication.
- The target of CcdB is the GyrA subunit of DNA gyrase, an essential type II topoisomerase in " Escherichia coli ".
- For many gram-negative bacteria, DNA gyrase is the target, whereas topoisomerase IV is the target for many gram-positive bacteria.
- Finally, mutations at key sites in DNA gyrase or topoisomerase IV can decrease their binding affinity to quinolones, decreasing the drugs'effectiveness.
- In addition, drug-resistant bacteria often have a point mutation in gyrase ( Serine79Alanine in E . coli ) that renders quinolones ineffective.
- Other mechanisms include de novo synthesis of a coumarin-resistant gyrase B subunit by the novobiocin producer " S . sphaeroides ".
- For many Gram-negative bacteria, DNA gyrase is the target, whereas topoisomerase IV is the target for many Gram-positive bacteria.
- Finally, mutations at key sites in DNA gyrase or topoisomerase IV can decrease their binding affinity to quinolones, decreasing the drug's effectiveness.
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