hirudin वाक्य
उदाहरण वाक्य
मोबाइल
- Hirudin is made by genetic engineering from the anticoagulant in the saliva of leeches, and it is being intensively studied in the hope that it will prove more effective than heparin.
- Participants received either heparin or hirudin along with drugs that can break up blood clots after they form, including streptokinase and TPA, and aspirin, which is also used to prevent clots.
- Bleeding time will vary, with location, from a few hours to three days . This is a function of the hirudin and other compounds that reduce the surface tension of the blood.
- In Topol's study, 26 of 2, 564 heart attack patients who received either hirudin or heparin suffered a stroke from bleeding in the brain, a rate of about 1 percent.
- A third study was conducted in Germany and was halted in June after researchers there, alerted to results of the two American based studies, found a similar risk of strokes among individuals receiving hirudin.
- 1884 : John Berry Haycraft has been actively engaged in research and published papers on the coagulation of blood and in 1884, he discovers that the leech secretes a powerful anticoagulant, which he names hirudin.
- When Germany's legislature passed the Genetic Engineering Act last May to encourage biotechnology at home, Hoechst applied to make Hirudin out of baker's yeast, but ran into a logjam from local politicians.
- They use a combination of mucus and suction ( caused by concentric muscles in those six segments ) to stay attached and secrete an anti-clotting enzyme, hirudin, into the host's blood stream.
- Researchers used the larger doses of heparin and hirudin in the studies because they appeared safe in all the pilot studies and because some patients, particularly those who were overweight, apparently did not receive large enough amounts of heparin.
- Unlike thrombin, reptilase is resistant to inhibition by antithrombin III . Thus, the reptilase time is not prolonged in blood samples containing heparin, hirudin, or direct thrombin inhibitors, whereas the thrombin time will be prolonged in these samples.
- Another drug made from " E . carinatus " venom is called " ecarin " and is the primary reagent in the ecarin clotting time ( ECT ) test, which is used to monitor anticoagulation during treatment with hirudin.
- Outstanding structures are those of procarboxypeptidase, which led to the discovery of the remarkable activation mechanism of this enzyme, and of the complex of thrombin with hirudin, which showed the molecular mechanism of inhibition of blood clotting by this leech toxin.
- The three studies found that among those receiving either heparin or hirudin with streptokinase or TPA there was " definitive evidence of a catastrophic bleeding complication " that was about twice the expected rate, the heart association said in a news release.
- This has led to the development and marketing of a number of hirudin-based anticoagulant pharmaceutical products, such as lepirudin ( Refludan ), hirudin derived from " Hansenula " ( Thrombexx, Extrauma ) and desirudin ( Revasc / Iprivask ).
- This has led to the development and marketing of a number of hirudin-based anticoagulant pharmaceutical products, such as lepirudin ( Refludan ), hirudin derived from " Hansenula " ( Thrombexx, Extrauma ) and desirudin ( Revasc / Iprivask ).
- The leech's natural anticoagulant, hirudin, keeps blood flowing for the 20 to 40 minutes it takes to feed, during which time the leech's body weight may increase 10 times, reaching up to 60 grams ( about two ounces ).
- Beyond these two proteins, other notable protein substrates include Cholecystokinin ( CCK ), Factor V and Factor VIII, gastrin, the leech enzyme hirudin, fibrinogen, Complement component 4, follicle-stimulating hormone receptor ( FSHR ), and other chemokine and G-protein coupled receptors.
- In the study headed by Dr . Eugene Braunwald and Dr . Elliott M . Antman of Harvard Medical School in Boston, 6 of 345, or 1.7 percent of those receiving hirudin and 7 of 368, or 1.9 percent of patients receiving heparin, suffered strokes from bleeding.
- During his years in Birmingham and Edinburgh, Haycraft had been actively engaged in research and published papers on the coagulation of blood and in 1884, he discovered that the leech secreted a powerful anticoagulant, which he named hirudin, although it was not isolated until the 1950s, nor its structure fully determined until 1976.
- Officials at the FDA, which had approved the studies, said their focus in reviewing the findings of the three studies was on hirudin because it was the experimental drug being compared with the standard one, heparin, and that they approved resumption of the hirudin trials because they did not want to inhibit research progress of a potentially important drug.
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