neurofibroma वाक्य
उदाहरण वाक्य
मोबाइल
- However, radiation is generally not used as a treatment for plexiform neurofibromas because of concerns that this could actually promote malignant transformation.
- Internal plexiform neurofibromas are very difficult to remove completely because they extend through multiple layers of tissue and the attempt would damage healthy tissue or organs.
- Se trata de tumores denominados neurofibromas, que aparecen en los nervios de cualquier parte del cuerpo, pero en mucha mayor proporcion en los nervios auditivos.
- For many NF-1 patients, a primary concern is the disfigurement caused by cutaneous / dermal neurofibromas, pigmented lesions, and the occasional limb abnormalities.
- While nonmyelinating Schwann cells are the origin of neurofibromas, the mutations that make them susceptible to this transformation occur in Schwann cell precursors during early nerve development.
- Neurofibromas arise from nonmyelinating Schwann cells that only express the inactive version of the NF1 gene, which leads to a complete loss of expression of functional neurofibromin.
- It has been hypothesized that the proliferating nonmyelinating Schwann cells secrete chemoattractants such as the survival factors that alter the developing tumor microenvironment and result in neurofibroma formation.
- Features common in neurofibromatosis-Lisch nodules, bone abnormalities, neurofibromas, optic pathway gliomas and malignant peripheral nerve sheath tumors-are absent in this condition.
- For treatment of progressive plexiform neurofibromas associated with neurofibromatosis type I, early research has shown potential for using the c-KIT tyrosine kinase blocking properties of imatinib.
- Masses in the posterior portion of the mediastinum tend to be neurogenic in origin, and in adults tend to be of neural sheath origin including neurilemomas and neurofibromas.
- Other tumor-suppressor genes that are exceptions to the " two-hit " rule are those that exhibit haploinsufficiency, including PTCH in medulloblastoma and NF1 in neurofibroma.
- It is unknown at this time why, if both types of Schwann cells exhibit bilallelic inactivation of the NF1 gene, only the nonmyelinating variety give rise to neurofibromas.
- The latter had, through the years, been variously described as Bizarre cutaneous neurofibroma, Myxoma of nerve sheath, and Pacinian neurofibroma .
- The latter had, through the years, been variously described as Bizarre cutaneous neurofibroma, Myxoma of nerve sheath, and Pacinian neurofibroma .
- While one defective allele may be inherited, loss of heterozygosity ( LOH ) must occur before a neurofibroma can form; this is called the two-hit hypothesis.
- The formation of malignant cancers from neurofibromas is associated with the loss of expression of the CDKN2A or TP53 gene in non-myelinating Schwann cells that also exhibit biallelic inactivation of the NF1 gene.
- The grants cover an array of studies, from the genetics of triple-negative breast cancer to imaging of precancerous pancreatic lesions; from neurofibroma tumorigenesis and therapy to the molecular mechanisms of the body s natural killer cells against multiple myeloma; from the role of the ATF3 gene in the development and treatment of chronic lymphocytic leukemia to genomic aberrations driving metastatic squamous cell carcinoma ( a type of skin cancer ).
- In tumors, CD34 is found in alveolar soft part sarcoma, preB-ALL ( positive in 75 % ), AML ( 40 % ), AML-M7 ( most ), dermatofibrosarcoma protuberans, gastrointestinal stromal tumors, giant cell fibroblastoma, granulocytic sarcoma, Kaposi s sarcoma, liposarcoma, malignant fibrous histiocytoma, malignant peripheral nerve sheath tumors, mengingeal hemangiopericytomas, meningiomas, neurofibromas, schwannomas, and papillary thyroid carcinoma.
- Axillary freckling also occurs in other disease processes that closely resemble NF1, such as Legius syndrome ( cafe-au-lait spots, axillary freckling, and macrocephaly without Lisch nodules, neurofibromas or CNS tumors ), and, homozygous HNPCC mutations ( cafe-au-lait spots, axillary freckling, and cutaneous neurofibromas in the setting of Hereditary Non-Polyposis Colon Cancer, also known as Lynch syndrome; seen with family history of HNPCC and consanguinity)
- Axillary freckling also occurs in other disease processes that closely resemble NF1, such as Legius syndrome ( cafe-au-lait spots, axillary freckling, and macrocephaly without Lisch nodules, neurofibromas or CNS tumors ), and, homozygous HNPCC mutations ( cafe-au-lait spots, axillary freckling, and cutaneous neurofibromas in the setting of Hereditary Non-Polyposis Colon Cancer, also known as Lynch syndrome; seen with family history of HNPCC and consanguinity)
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