pregnenolone वाक्य
उदाहरण वाक्य
मोबाइल
- The sugar-free ( aglycone ), diosgenin is used for the commercial synthesis of cortisone, pregnenolone, progesterone, and other steroid products.
- Pregnenolone, nicknamed preg, is the hormone from which the body makes DHEA, which is then converted into estrogen, testosterone and other vital hormones.
- The development of the corpus luteum is accompanied by an increase in the level of the steroidogenic enzyme P450scc that converts cholesterol to pregnenolone in the mitochondria.
- As a result, higher levels of 17OH-pregnenolone appear in the blood with adrenocorticotropic hormone ( ACTH ) challenge, which stimulates adrenal corticosteroid synthesis.
- In humans the reticularis layer does contain 17 alpha-hydroxylase; this hydroxylates pregnenolone, which is then converted to cortisol by a mixed function oxidase.
- Another study found that allopregnanolone levels were increased by 3-fold at 2 hours post-administration following a single 400 mg oral dose of pregnenolone.
- "' 17?-Hydroxypregnenolone "'is a pregnane ( C21 ) steroid that is obtained by hydroxylation of pregnenolone at the C17? position.
- Although pregnenolone itself does not possess these activities, its metabolite pregnenolone sulfate is a negative allosteric modulator of the pancreatic islets causing calcium entry and subsequent insulin release.
- Although pregnenolone itself does not possess these activities, its metabolite pregnenolone sulfate is a negative allosteric modulator of the pancreatic islets causing calcium entry and subsequent insulin release.
- Jenapharm developed an alternate process starting from hyodesoxycholic acid extracted from hog bile, from which they first produced pregnenolone, and subsequently progesterone and desoxycorticosterone acetate in 1954 / 1955.
- It also stimulates the main rate-limiting step in cortisol synthesis, in which cholesterol is converted to pregnenolone and catalyzed by cytochrome P450SCC ( side-chain cleavage enzyme ).
- By inhibiting 3?-HSD, epostane blocks the biosynthesis of progesterone from pregnenolone ( and also the conversion of dehydroepiandrosterone to androstenedione ), thereby functioning as an antiprogestogen and terminating pregnancy.
- Sahelian's newest book, " Pregnenolone : Nature's Feel Good Hormone " ( Avery Publishing Group, $ 9.95 ), will be out in June.
- After two years, Glidden abandoned production of cortisone to concentrate on Substance S . Julian developed a multistep process for conversion of pregnenolone, available in abundance from soybean oil sterols, to cortexolone.
- If DHEA is the mother of all hormones, pregnenolone is the grandmother, says Dr . Ray Sahelian, whose books on melatonin, DHEA and creatine helped catapult those chemicals into the national consciousness.
- An endogenous ligand for the ? 1 receptor has yet to be conclusively identified, but tryptaminergic trace amines, as well as neuroactive steroids such as dehydroepiandrosterone ( DHEA ) and pregnenolone all activate the receptor.
- In addition to its glucocorticoid effects, pregnenolone succinate has been found to act as a negative allosteric modulator of the GABA A receptor and a positive allosteric modulator of the NMDA receptor similarly to pregnenolone sulfate.
- In addition to its glucocorticoid effects, pregnenolone succinate has been found to act as a negative allosteric modulator of the GABA A receptor and a positive allosteric modulator of the NMDA receptor similarly to pregnenolone sulfate.
- When researchers added either progesterone or pregnenolone close to the damaged nerves, they said, there was a significant increase in the thickness of new myelin sheaths, which appeared normal in structure when examined under an electron microscope.
- It has been found to act like a partial agonist of an allosteric site of the EC 50 that is more than an order of magnitude lower than that of other endogenous pregnanes like pregnenolone, pregnanediol, allopregnanedione, and allopregnanolone.
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