gyrase वाक्य
उदाहरण वाक्य
मोबाइल
- Fluoroquinolones were a useful next-line treatment until resistance was achieved through efflux pumps and mutations to the gyrA gene, which encodes DNA gyrase.
- DNA gyrase is an important enzyme that introduces a negative supercoil to the DNA and is responsible for the biological processes in DNA replication and transcription.
- In Gram-negative bacteria, plasmid-mediated resistance genes produce proteins that can bind to DNA gyrase, protecting it from the action of quinolones.
- In gram-negative bacteria, plasmid-mediated resistance genes produce proteins that can bind to DNA gyrase, protecting it from the action of quinolones.
- The ability of gyrase ( and topoisomerase IV ) to relax positive supercoils allows superhelical tension ahead of the polymerase to be released so that replication can continue.
- For one thing, the microbe appears to have only one gene, called a reverse gyrase, that is not found in organisms that live at ordinary temperatures.
- RNAs are always found in the presumed 5'untranslated regions of " gyrA " genes, which encodes a protein forming a subunit of a DNA gyrase.
- It functions by inhibiting DNA gyrase, a type II topoisomerase, and topoisomerase IV, which is an enzyme necessary to separate, replicated DNA, thereby inhibiting cell division.
- Glutamate racemase ( MurI ) serves two distinct metabolic functions : primarily, it is a critical enzyme in cell wall biosynthesis, but also plays a role in gyrase inhibition.
- DNA gyrase was incubated with the MurI enzyme and then added to a sample of DNA; the results of this experiment showed inhibition of supercoiling activity when MurI was present.
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