Both pathways result in membrane loss, decreased surface area, and formation of spherocytes with decreased deformability.
2.
As the spleen normally targets abnormally shaped red cells ( which are typically older ), it also destroys spherocytes.
3.
Though the spherocytes have a smaller surface area through which oxygen and carbon dioxide can be exchanged, they in themselves perform adequately to maintain healthy oxygen supplies.
4.
Bite cells and / or blistor cells for oxidative hemolysis, Acanthocytes for pyruvate kinase deficiency or McLeod phenotype, Sickle cells for sickle cell anemia, Spherocytes for immune-mediated hemolysis or hereditary spherocytosis, Elliptocytosis for iron deficiency or hereditary elliptocytosis and schistocytes for intravascular hemolysis.
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