steatocystoma वाक्य
उदाहरण वाक्य
मोबाइल
- Steatocystoma multiplex is often associated with eruptive vellus hair cysts ( EVHCs ).
- Sporadic forms of steatocystoma multiplex have not been shown to be associated with K17 mutations.
- In steatocystoma multiplex associated with eruptive vellus hair cyst, no K17 mutation has been found.
- Reports of hybrid lesions showing histological features of both steatocystoma multiplex and eruptive vellus hair cysts exist.
- Mutations in the gene encoding this protein lead to Jackson-Lawler type pachyonychia congenita and steatocystoma multiplex.
- Steatocystoma multiplex occurs as either a sporadic or autosomal dominant inherited condition characterized by benign sebaceous gland tumors.
- The relationship of steatocystoma multiplex to the development of sebaceous glands and common presentation at puberty suggest a hormonal trigger for lesion growth.
- Some authors propose that steatocystoma multiplex is simply a variant of pachyonychia congenita type 2 because they both share the same underlying etiology.
- Given these similarities, some postulate that steatocystoma multiplex and eruptive vellus hair cysts are, in fact, variants of the same disease.
- Steatocystoma suppurativa : Treatment is indicated for this scarring inflammatory version of the disorder and involves antimicrobial therapy in combination with incision and drainage.
- However, major differences in keratin expression patterns between steatocystoma multiplex and eruptive vellus hair cysts have been elucidated, leading others to believe that they are 2 distinct disease entities.
- In previous reports, specific mutations were attributed to early-onset cyst formation in pachyonychia congenita type 2 and steatocystoma multiplex; however, more recent reports suggest that the age of onset is multifactorial.
- In the familial form of steatocystoma multiplex, mutations are localized to the keratin 17 ( K17 ) gene in areas identical to mutations found in patients with pachyonychia congenita type 2 ( PC-2 ).
- To date, 14 mutations have been described in patients with either steatocystoma multiplex or pachyonychia congenita type 2, all of which are localized to the helix initiation domain ( 1A domain ) of the K17 gene.
- Therefore, technically speaking they are not sebaceous cysts . " True " sebaceous cysts, cysts which originate from sebaceous glands and which contain sebum, are relatively rare and are known as steatocystoma simplex or, if multiple, as steatocystoma multiplex.
- Therefore, technically speaking they are not sebaceous cysts . " True " sebaceous cysts, cysts which originate from sebaceous glands and which contain sebum, are relatively rare and are known as steatocystoma simplex or, if multiple, as steatocystoma multiplex.
- Keratin 17 is expressed in several epithelial structures, most notably in sebaceous glands, the outer root sheath of hair follicles, and the nail bed; its expression correlates well to the clinical phenotypic expression of both steatocystoma multiplex and pachyonychia congenita type 2.
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