This is consistent with the anatomy of neocortical networks because the most powerful reciprocal layer connections are in supragranular layers 2 and 3.
2.
This may resolve the conflicting information suggesting that the activity spreads primarily at the supragranular layers or at the large layer 5 neurons.
3.
Layer 4 granule cells of the cerebral cortex receive inputs from the thalamus and send projections to supragranular layers 2-3, but also to infragranular layers of the cerebral cortex.
4.
However, measurements from both somatic and dendritic patch recordings show that the peak membrane potential deflection during a paroxysmal depolarizing shift ( PDS ) is 10mV greater in the apical trunk ( supragranular location ) than the soma.
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