| 1. | Nucleophilic attack of trigonelline was a known reaction at that time.
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| 2. | Higher levels of trigonelline is found in arabica coffee.
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| 3. | Trigonelline is a product of niacin metabolism that is excreted in urine of mammals.
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| 4. | Trigonelline is a methyl betaine of nicotinic acid.
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| 5. | Without sugar it shouldn't lead to chemical responsible appears to be trigonelline.
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| 6. | Trigonelline enhances the nucleophilic nature of nicotinic acid.
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| 7. | Mutagenic activity of trigonelline has been reported.
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| 8. | Trigonelline is also found in coffee.
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| 9. | Figure 2 : Major synthetic steps leading to dioscorine from trigonelline precursor in "'Dioscorea hispida "'
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| 10. | Active ingredinets of this herb include : methionine, glycine, ?-aminobutyric acid, ephedrine, trigonelline, phytosterols and glucoronic acid.
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